Regulation and secretion of plasminogen activators and their inhibitors in a human leukemic cell line (K562).

Regulation and Secretion of Plasminogen Activators and Their Inhibitors in a Human Leukemic Cell

The secretion of tissue plasminogen activator ft-PA). urokinase (u-PA) and their inhibitors by the human leukemia cell line K562 was examined. K562 cells normally secrete both t -PA and u-PA in a ratio of 3:1 . After addition of 10 or 1 ng/mL phorbol myristate acetate (PMA) to K562 cells. a marked decrease in enzymatic activity is observed in the medium. However. when t-PA antigen rather than a...

Role of Phosphoramidate Antisense in Specific Inhibition of K562 Leukemic Cell Line

Evaluation of cytotoxicity mechanism of two cyclo-oxygenase-2 inhibitors in leukemia cell line

Introduction: Leukemia is considered one of the main causes of death, and current chemotherapeutic agents are unable to provide optimal responses due to chemo-resistance. Therefore, there is a constant need for new drugs. Cyclooxygenase- 2 (COX-2) inhibitors can be helpful by reducing the necessary dose of routine chemotherapeutic drugs. Herein, we evaluated the cytotoxicity activity as well...

Expression Pattern of Interferon-γ in Human Leukemic T Cell Lines Following Treatment with Phytoheamagglutinin, phorbol myristate acetate and Lipopolysaccharide

Background: As a T helper type 1 (Th1) derived cytokine, Interferon gamma (IFN-γ) is an important regulator of inflammatory immune responses. Furthermore, IFN-γ plays an essential role in defense against tumors and intracellular pathogens. This study was designed to assess the pattern of IFN-γ production in human leukemic (Jurkat and Molt-4) T cell lines in vitro. Methods: Ju...

تأثیر آدنوزین ´5تری فسفات در القای آپوپتوز و مهار بیان ژن Survivin و واریانت پیرایشی ضد آپوپتوزی SUR-3B آن در سلول های K562

Introduction: Leukemia is a heterogeneous malignant disease in which progression at the level of CD34+ cells has a major impact in drug resistance and relapse. The multi-drug resistance gene product, P-glycoprotein is an inhibitor of apoptosis proteins (IAPs), such as Survivin that are expressed simultaneously with several putative drug resistance parameters in CD34+ leukemia cells. In fact, IA...